InnateDB Protein
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IDBP-183342.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kifc3
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Protein Name
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kinesin family member C3
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Synonyms
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AI325457; BB123200;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034240
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InnateDB Gene
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IDBG-183340 (Kifc3)
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Protein Structure
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Function |
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance. {ECO:0000269PubMed:11581287}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:11581287}. Cytoplasmic vesicle membrane {ECO:0000305PubMed:11581287}; Peripheral membrane protein {ECO:0000305PubMed:11581287}. Cell junction, adherens junction {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes along zonula adherens only at mature cell-cell contacts (By similarity). Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominant expression in the kidney, testis and ovary. Also expressed in brain, heart, liver, lung and uterus. {ECO:0000269PubMed:11581287}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:109202
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InterPro |
IPR001752
Kinesin, motor domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00225
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PRINTS |
PR00380
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PIRSF |
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SMART |
SM00129
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TIGRFAMs |
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Modification |
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SwissProt |
O35231
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PhosphoSite |
PhosphoSite-O35231
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
16582
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UniGene |
Mm.378951
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RefSeq |
NP_034761
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MGI ID |
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MGI Symbol |
Kifc3
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OMIM |
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CCDS |
CCDS52640
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HPRD |
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IMGT |
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EMBL |
AB001457
AF013118
AK132895
AK135926
BC004069
BC016118
BC023374
BC070429
D49546
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GenPept |
AAC39967
AAH04069
AAH16118
AAH23374
AAH70429
BAA22399
BAE21409
BAE22727
BAE92567
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