InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kifc3

Summary

InnateDB Gene

IDBG-183340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kifc3

Gene Name

kinesin family member C3

Synonyms

AI325457; BB123200

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031788

Encoded Proteins

IDBP-183342

kinesin family member C3

IDBP-621616

kinesin family member C3

IDBP-621620

kinesin family member C3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140859:
KIFC3 belongs to the large superfamily of kinesins, molecular motors that use the energy of ATP hydrolysis to translocate cargoes along microtubules. Members share extensive homology within a globular domain containing the microtubule- and ATP-binding sites and have a coiled-coil stalk domain that mediates oligomerization. Different kinesin family members participate in specific and diverse motile processes, such as cell division, organelle transport, and nuclear movement (Hoang et al., 1998 [PubMed 9782090]).[supplied by OMIM, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:95099832-95142540

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034240	ENSMUSP00000034240
ENSMUST00000169748	ENSMUSP00000126784
ENSMUST00000169353	ENSMUSP00000127427

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008569	minus-end-directed microtubule motor activity

Biological Process

GO:0007017	microtubule-based process
GO:0007018	microtubule-based movement
GO:0007030	Golgi organization
GO:0008152	metabolic process
GO:0045218	zonula adherens maintenance
GO:0090136	epithelial cell-cell adhesion

Cellular Component

GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005915	zonula adherens
GO:0030659	cytoplasmic vesicle membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000140859

View Gene Order

ENSBTAG00000007181

Not yet available

Pathways

NETPATH

REACTOME

REACT_258900

Chaperonin-mediated protein folding pathway

REACT_244970

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_247926

Metabolism of proteins pathway

REACT_245534

Protein folding pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

ecadherin_stabilization_pathway

Stabilization and expansion of the E-cadherin adherens junction

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.378951

RefSeq

NM_001145831 NM_001145832 NM_010631

OMIM

CCDS

CCDS52638 CCDS52639 CCDS52640

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas