InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Guca2b

Summary

InnateDB Protein

IDBP-183369.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Guca2b

Protein Name

guanylate cyclase activator 2b (retina)

Synonyms

AV066530; Gcap2; Ugn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043203

InnateDB Gene

IDBG-183367 (Guca2b)

Protein Structure

UniProt Annotation

Function

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Localized predominantly in intestinal villi and the corticomedullary junction of the kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008047	enzyme activator activity

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007588	excretion
GO:0007589	body fluid secretion
GO:0030802	regulation of cyclic nucleotide biosynthetic process
GO:0043085	positive regulation of catalytic activity
GO:0045776	negative regulation of blood pressure