Version 5.4
Mus musculus Gene: Guca2b
Summary
InnateDB Gene IDBG-183367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Guca2b
Gene Name guanylate cyclase activator 2b (retina)
Synonyms AV066530; Gcap2; Ugn
Species Mus musculus
Ensembl Gene ENSMUSG00000032978
Encoded Proteins
IDBP-183369
guanylate cyclase activator 2b (retina)
IDBP-269036
guanylate cyclase activator 2b (retina)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000044012:
This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:119656607-119658954
Strand Reverse strand
Band D2.1
Transcripts
ENSMUST00000044426 ENSMUSP00000043203
ENSMUST00000106309 ENSMUSP00000101916
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008047 enzyme activator activity
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0007588 excretion
GO:0007589 body fluid secretion
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0043085 positive regulation of catalytic activity
GO:0045776 negative regulation of blood pressure
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000044012
View Gene Order
ENSBTAG00000007194
Not yet available
Cross-References
SwissProt O09051
TrEMBL A2AA35 Q9QUQ3
UniProt Splice Variant
Entrez Gene 14916
UniGene
RefSeq NM_008191
OMIM
CCDS CCDS18587
HPRD
IMGT
MGI ID MGI:1270851
MGI Symbol Guca2b
EMBL AF006668 AK002364 AL645563 BC024373 CH466552 U67800 U90727 U95182
GenPept AAB53314 AAB82750 AAD09215 AAD09311 AAH24373 BAB22042 EDL30433
RNA Seq Atlas 14916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca