InnateDB Protein
|
IDBP-18365.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SERPINA5
|
Protein Name
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
|
Synonyms
|
PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000333203
|
InnateDB Gene
|
IDBG-18363 (SERPINA5)
|
Protein Structure
|
|
Function |
Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary- type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid. {ECO:0000269PubMed:10340997, ECO:0000269PubMed:11722589, ECO:0000269PubMed:14696115, ECO:0000269PubMed:15140131, ECO:0000269PubMed:15328353, ECO:0000269PubMed:15853774, ECO:0000269PubMed:1725227, ECO:0000269PubMed:18467335, ECO:0000269PubMed:2844223, ECO:0000269PubMed:3501295, ECO:0000269PubMed:6323392, ECO:0000269PubMed:7521127, ECO:0000269PubMed:7548057, ECO:0000269PubMed:8536714, ECO:0000269PubMed:8665956, ECO:0000269PubMed:9473218, ECO:0000269PubMed:9510955, ECO:0000269PubMed:9556620}.
|
Subcellular Localization |
Secreted, extracellular space {ECO:0000269PubMed:1725227, ECO:0000269PubMed:18467335, ECO:0000269PubMed:7521127, ECO:0000269PubMed:8536714, ECO:0000269PubMed:9510955, ECO:0000269PubMed:9556620}. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
|
Disease Associations |
|
Tissue Specificity |
Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate. {ECO:0000269PubMed:1372913, ECO:0000269PubMed:14696115, ECO:0000269PubMed:15140131, ECO:0000269PubMed:17706750, ECO:0000269PubMed:18467335, ECO:0000269PubMed:9510955, ECO:0000269PubMed:9556620}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
|
Protein-Protein |
16
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR023796
Serpin domain
|
PFAM |
PF00079
|
PRINTS |
|
PIRSF |
|
SMART |
SM00093
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P05154
|
PhosphoSite |
PhosphoSite-P05154
|
TrEMBL |
G3V4B4
|
UniProt Splice Variant |
|
Entrez Gene |
5104
|
UniGene |
Hs.596279
|
RefSeq |
NP_000615
|
HUGO |
HGNC:8723
|
OMIM |
601841
|
CCDS |
CCDS9928
|
HPRD |
03503
|
IMGT |
|
EMBL |
AF361796
AL049839
AL080185
BC008915
CH471061
J02639
M68516
S58545
S69364
S69365
S69366
S69574
U35464
|
GenPept |
AAA02811
AAA35688
AAB26244
AAB30461
AAB60386
AAH08915
AAK27240
CAB45766
EAW81582
EAW81583
EAW81584
EAW81585
EAW81586
|
|
|