InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnq4

Summary

InnateDB Protein

IDBP-183831.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnq4

Protein Name

potassium voltage-gated channel, subfamily Q, member 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030376

InnateDB Gene

IDBG-183829 (Kcnq4)

Protein Structure

UniProt Annotation

Function

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea.

Subcellular Localization

Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells.

Disease Associations

Tissue Specificity

In the inner ear expressed in the outer sensory hair cells of the cochlea and in type I hair cells of the vestibular organs. Also expressed in the postsynaptic membrane of the calyx nerve endings innervating type I cells. In the brain expressed in neurons of many, but not all, nuclei of the central auditory pathway. Absent from most other brain regions. {ECO:0000269PubMed:10760300}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007605	sensory perception of sound
GO:0034765	regulation of ion transmembrane transport
GO:0042472	inner ear morphogenesis
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1926803

InterPro

IPR003091 Potassium channel
IPR003937 Potassium channel, voltage dependent, KCNQ
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal

PFAM

PF00520
PF07885
PF03520

PRINTS

PR00169
PR01459

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JK97