InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nckap1

Summary

InnateDB Protein

IDBP-183837.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nckap1

Protein Name

NCK-associated protein 1

Synonyms

C79304; H19; Hem-2; Hem2; mh19; mKIAA0587; Nap1; p125Nap1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028386

InnateDB Gene

IDBG-183835 (Nckap1)

Protein Structure

UniProt Annotation

Function

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. {ECO:0000269PubMed:14765121}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14765121}; Single-pass membrane protein {ECO:0000269PubMed:14765121}; Cytoplasmic side {ECO:0000269PubMed:14765121}. Cell projection, lamellipodium membrane {ECO:0000269PubMed:14765121}; Single-pass membrane protein {ECO:0000269PubMed:14765121}; Cytoplasmic side {ECO:0000269PubMed:14765121}. Cytoplasm {ECO:0000269PubMed:14765121}. Note=At the interface between the lamellipodial actin meshwork and the membrane.

Disease Associations

Tissue Specificity

High expression in cerebral cortex, not in cerebellar cortex.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0007354	zygotic determination of anterior/posterior axis, embryo
GO:0007492	endoderm development
GO:0008078	mesodermal cell migration
GO:0010172	embryonic body morphogenesis
GO:0010592	positive regulation of lamellipodium assembly
GO:0016601	Rac protein signal transduction
GO:0030032	lamellipodium assembly
GO:0030903	notochord development
GO:0030950	establishment or maintenance of actin cytoskeleton polarity
GO:0032880	regulation of protein localization
GO:0035050	embryonic heart tube development
GO:0042074	cell migration involved in gastrulation
GO:0045175	basal protein localization
GO:0045176	apical protein localization
GO:0048339	paraxial mesoderm development
GO:0048340	paraxial mesoderm morphogenesis
GO:0048570	notochord morphogenesis
GO:0048617	embryonic foregut morphogenesis
GO:0050821	protein stabilization
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation

Cellular Component

GO:0005737	cytoplasm
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0031209	SCAR complex
GO:0031258	lamellipodium membrane
GO:0070062	extracellular vesicular exosome