InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: D2hgdh

Summary

InnateDB Protein

IDBP-183949.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

D2hgdh

Protein Name

D-2-hydroxyglutarate dehydrogenase

Synonyms

AA408776; AA408778; AI325464;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095235

InnateDB Gene

IDBG-183947 (D2hgdh)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0050660	flavin adenine dinucleotide binding
GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity

Biological Process

GO:0010042	response to manganese ion
GO:0010043	response to zinc ion
GO:0032025	response to cobalt ion
GO:0044267	cellular protein metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:2138209

InterPro

IPR004113 FAD-linked oxidase, C-terminal
IPR006094 FAD linked oxidase, N-terminal
IPR016164 FAD-linked oxidase-like, C-terminal
IPR016166 FAD-binding, type 2

PFAM

PF02913
PF01565

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CIM3

PhosphoSite