InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd2ap

Summary

InnateDB Protein

IDBP-183952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd2ap

Protein Name

CD2-associated protein

Synonyms

AL024079; C78928; METS-1; Mets1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024709

InnateDB Gene

IDBG-183950 (Cd2ap)

Protein Structure

UniProt Annotation

Function

Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. {ECO:0000269PubMed:10514378}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, ruffle. Note=During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (By similarity). Located at podocyte slit diaphragm between podocyte foot processes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in podocytes (at protein level). {ECO:0000269PubMed:18753381}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005172	vascular endothelial growth factor receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0017124	SH3 domain binding
GO:0032403	protein complex binding
GO:0045296	cadherin binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0016050	vesicle organization
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0032911	negative regulation of transforming growth factor beta1 production
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048259	regulation of receptor-mediated endocytosis
GO:1900182	positive regulation of protein localization to nucleus
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0001726	ruffle
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005938	cell cortex
GO:0030139	endocytic vesicle
GO:0031941	filamentous actin
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome