InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctps2

Summary

InnateDB Protein

IDBP-183970.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctps2

Protein Name

cytidine 5'-triphosphate synthase 2

Synonyms

A830031M15Rik; AI326475; Ctpsh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033727

InnateDB Gene

IDBG-183964 (Ctps2)

Protein Structure

UniProt Annotation

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006541	glutamine metabolic process
GO:0044210	'de novo' CTP biosynthetic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1933185

InterPro

IPR004468 CTP synthase
IPR011697 Peptidase C26
IPR017456 CTP synthase, N-terminal
IPR017926 Glutamine amidotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029062 Class I glutamine amidotransferase-like

PFAM

PF07722
PF06418
PF00117

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70303

PhosphoSite