InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dyx1c1

Summary

InnateDB Protein

IDBP-183978.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dyx1c1

Protein Name

dyslexia susceptibility 1 candidate gene 1 protein homolog isoform 2

Synonyms

1700010I24Rik; b2b811Clo; EKN1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034734

InnateDB Gene

IDBG-606025 (Dyx1c1)

Protein Structure

UniProt Annotation

Function

Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (By similarity). Axonemal dynein assembly factor required for ciliary motility. {ECO:0000250, ECO:0000269PubMed:23872636}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:23872636}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0030331	estrogen receptor binding

Biological Process

GO:0001764	neuron migration
GO:0003341	cilium movement
GO:0007368	determination of left/right symmetry
GO:0033146	regulation of intracellular estrogen receptor signaling pathway
GO:0036158	outer dynein arm assembly
GO:0036159	inner dynein arm assembly
GO:0061136	regulation of proteasomal protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914935

InterPro

IPR001440 Tetratricopeptide TPR1
IPR007052 CS domain
IPR008978 HSP20-like chaperone
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF04969
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R368