InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sphk2

Summary

InnateDB Protein

IDBP-184181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sphk2

Protein Name

sphingosine kinase 2

Synonyms

C76851;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072615

InnateDB Gene

IDBG-184179 (Sphk2)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008481	sphinganine kinase activity
GO:0017050	D-erythro-sphingosine kinase activity

Biological Process

GO:0001568	blood vessel development
GO:0006669	sphinganine-1-phosphate biosynthetic process
GO:0006670	sphingosine metabolic process
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0046834	lipid phosphorylation