InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sphk2

Summary

InnateDB Gene

IDBG-184179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sphk2

Gene Name

sphingosine kinase 2

Synonyms

C76851

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057342

Encoded Proteins

IDBP-184181

sphingosine kinase 2

IDBP-266036

sphingosine kinase 2

IDBP-266038

sphingosine kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45709467-45718002

Strand

Reverse strand

Band

Transcripts

ENSMUST00000072836	ENSMUSP00000072615
ENSMUST00000107738	ENSMUSP00000103367
ENSMUST00000107737	ENSMUSP00000103366

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008481	sphinganine kinase activity
GO:0017050	D-erythro-sphingosine kinase activity

Biological Process

GO:0001568	blood vessel development
GO:0006669	sphinganine-1-phosphate biosynthetic process
GO:0006670	sphingosine metabolic process
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0046834	lipid phosphorylation