InnateDB Protein
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IDBP-184190.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Klf12
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Protein Name
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Kruppel-like factor 12
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Synonyms
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2700063E05Rik; AI225908; AI315654; AP-2rep; B130052C06Rik; D530033K05Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000094844
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InnateDB Gene
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IDBG-184188 (Klf12)
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Protein Structure
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Function |
Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0001227
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RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0046872
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metal ion binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:1333796
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
O35738
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PhosphoSite |
PhosphoSite-O35738
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
16597
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UniGene |
Mm.458816
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RefSeq |
NP_034766
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MGI ID |
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MGI Symbol |
Klf12
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OMIM |
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CCDS |
CCDS36998
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HPRD |
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IMGT |
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EMBL |
BC067408
Y14295
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GenPept |
AAH67408
CAA74670
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