Version 5.4
Mus musculus Gene: Klf12
Summary
InnateDB Gene IDBG-184188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klf12
Gene Name Kruppel-like factor 12
Synonyms 2700063E05Rik; AI225908; AI315654; AP-2rep; B130052C06Rik; D530033K05Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000072294
Encoded Proteins
IDBP-184190
Kruppel-like factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118922:
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:99874486-100149764
Strand Reverse strand
Band E2.3
Transcripts
ENSMUST00000097079 ENSMUSP00000094844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118922
View Gene Order
ENSBTAG00000044007
Not yet available
Cross-References
SwissProt O35738
TrEMBL
UniProt Splice Variant
Entrez Gene 16597
UniGene Mm.458816
RefSeq NM_010636 XM_006518623 XM_006518624 XM_006518625 XM_006518626
OMIM
CCDS CCDS36998
HPRD
IMGT
MGI ID MGI:1333796
MGI Symbol Klf12
EMBL BC067408 Y14295
GenPept AAH67408 CAA74670
RNA Seq Atlas 16597

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca