InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mep1a

Summary

InnateDB Protein

IDBP-184222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mep1a

Protein Name

meprin 1 alpha

Synonyms

AI098089; AW107200; Mep-1; Mep-1a; Mep1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024707

InnateDB Gene

IDBG-184220 (Mep1a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Kidney, intestinal brush borders and salivary ducts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0016020	membrane
GO:0017090	meprin A complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96963

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000998 MAM domain
IPR001506 Peptidase M12A, astacin
IPR002083 MATH
IPR006026 Peptidase, metallopeptidase
IPR008294 Meprin alpha/beta subunit
IPR008974 TRAF-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00629
PF01400
PF00917

PRINTS

PR00020
PR00480

PIRSF

PIRSF001196

SMART

SM00181
SM00137
SM00061
SM00235

TIGRFAMs

Post-translational Modifications

Modification

Cross-References