InnateDB Protein
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IDBP-18423.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIRT6
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Protein Name
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sirtuin 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305310
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InnateDB Gene
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IDBG-18419 (SIRT6)
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Protein Structure
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Function |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. {ECO:0000250, ECO:0000269PubMed:18337721, ECO:0000269PubMed:19135889, ECO:0000269PubMed:19625767, ECO:0000269PubMed:20829486, ECO:0000269PubMed:21362626}.
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Subcellular Localization |
Nucleus, nucleoplasm {ECO:0000269PubMed:16079181, ECO:0000269PubMed:18337721, ECO:0000269PubMed:19135889}. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
30
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003000
Sirtuin family
IPR026590
Sirtuin family, catalytic core domain
IPR029035
DHS-like NAD/FAD-binding domain
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PFAM |
PF02146
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N6T7
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PhosphoSite |
PhosphoSite-Q8N6T7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51548
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UniGene |
Hs.423756
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RefSeq |
NP_001180214
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HUGO |
HGNC:14934
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OMIM |
606211
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CCDS |
CCDS54199
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HPRD |
12093
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IMGT |
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EMBL |
AC005620
AC006930
AF233396
AK074810
AK315048
BC004218
BC005026
BC028220
CH471139
CR457200
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GenPept |
AAC34468
AAD15478
AAF43432
AAH04218
AAH05026
AAH28220
BAC11222
BAG37527
CAG33481
EAW69252
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