InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: St8sia4

Summary

InnateDB Protein

IDBP-184277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

St8sia4

Protein Name

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

Synonyms

PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043477

InnateDB Gene

IDBG-184275 (St8sia4)

Protein Structure

UniProt Annotation

Function

Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Strongly expressed in lung, heart and spleen and weakly in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373	sialyltransferase activity

Biological Process

GO:0001574	ganglioside biosynthetic process
GO:0006486	protein glycosylation
GO:0006491	N-glycan processing
GO:0009311	oligosaccharide metabolic process
GO:0097503	sialylation