InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLEC7A

Summary

InnateDB Protein

IDBP-18430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLEC7A

Protein Name

C-type lectin domain family 7, member A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000266456

InnateDB Gene

IDBG-18428 (CLEC7A)

Protein Structure

UniProt Annotation

Function

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11745369, ECO:0000269PubMed:16870151, ECO:0000269PubMed:17230442}; Single- pass type II membrane protein {ECO:0000269PubMed:11745369, ECO:0000269PubMed:16870151, ECO:0000269PubMed:17230442}.Isoform 5: Cytoplasm.Isoform 6: Cytoplasm {ECO:0000305}.Isoform 7: Cytoplasm {ECO:0000305}.

Disease Associations

Candidiasis, familial, 4 (CANDF4) [MIM:613108]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269PubMed:19864674}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269PubMed:11470510, ECO:0000269PubMed:11491532, ECO:0000269PubMed:11567029, ECO:0000269PubMed:11745369, ECO:0000269PubMed:12423684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008329	signaling pattern recognition receptor activity
GO:0030246	carbohydrate binding
GO:0042287	MHC protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006910	phagocytosis, recognition
GO:0006954	inflammatory response
GO:0008037	cell recognition
GO:0009756	carbohydrate mediated signaling
GO:0042110	T cell activation
GO:0042832	defense response to protozoan
GO:0045087	innate immune response (InnateDB)