Version 5.4
Homo sapiens Gene: CLEC7A
Summary
InnateDB Gene IDBG-18428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC7A
Gene Name C-type lectin domain family 7, member A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172243
Encoded Proteins
IDBP-18430
C-type lectin domain family 7, member A
IDBP-18432
C-type lectin domain family 7, member A
IDBP-18436
C-type lectin domain family 7, member A
IDBP-18438
C-type lectin domain family 7, member A
IDBP-18444
C-type lectin domain family 7, member A
IDBP-237394
C-type lectin domain family 7, member A
IDBP-594004
C-type lectin domain family 7, member A
IDBP-588628
C-type lectin domain family 7, member A
IDBP-587589
C-type lectin domain family 7, member A
IDBP-595593
C-type lectin domain family 7, member A
IDBP-603846
C-type lectin domain family 7, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 15956283
CLEC7A (Dectin-1) is a C-type lectin receptor that binds beta-glucan and is the primary receptor on macrophages for phagocytosis of various fungi.
PMID 17698636
CLEC7A synergizes with TLR2 to increase pro-inflammatory cytokine responses to pathogens.
PMID 19633936
CLEC7A has a critical role in the innate immune response against Mycobacterium tuberculosis in non-phagocytic cells in type II airway epithelial cells.
PMID 20100861
CLEC7A-dependent immune-cell recognition of beta glucan on the fungal cell-wall is modulated by the Candida albicans ERK-like-1 (CEK1)-mediated MAPK pathway, disruption of which causes enhanced cell-wall beta-glucan exposure triggering immune responses more efficiently than wild-type yeast.
PMID 21267996
CLEC7A, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. CLEC7A is coupled to SYK kinase and signals via CARD9 to activate NFKB, which in turns induces both innate and adaptive immunity.
PMID 21677049
CLEC7A is expressed mainly in dendritic cells and macrophages. CLEC7A recognizes beta-glucans with its carbohydrate recognition domain and transduces signals through its ITAM-like motif in the cytoplasmic region, which recruits SYK and initiates the CARD9/NFkB signalling cascade.
PMID 22267217
CLEC7A acts as an extracellular sensor for fungi and mycobacteria that induce both IL1B production and maturation for protective immunity.
PMID 22543832
The functional activity of CLEC7A in mucosal immunity to Candida albicans is dependent on the genetic background of the host. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 21267996
[Mus musculus] Clec7a, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. Clec7a is coupled to Syk kinase and signals via Card9 to activate NFKB, which in turns induces both innate and adaptive immunity.
PMID 21677049
[Mus musculus] Clec7a is expressed mainly in DCs and macrophages. Clec7a recognizes beta-glucans with its carbohydrate recognition domain and transduces signals through its ITAM-like motif in the cytoplasmic region, which recruits Syk and initiates the Card9/NFkB signalling cascade.
PMID 22267217
[Mus musculus] Clec7a acts as an extracellular sensor for fungi and mycobacteria that induce both Il1b production and maturation for protective immunity. (Demonstrated in human)
PMID 22543832
[Mus musculus] The functional activity of Clec7a in mucosal immunity to Candida albicans is dependent on the genetic background of the host; this was specifically observed in two strains of mice, C57BL/6 and BALB/c.
PMID 23386437
[Mus musculus] Clec7a is necessary for macrophage activation and resistance to pathogenic fungus Coccidioidesimmitis.
PMID 25538234
[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
Entrez Gene
Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:10116777-10130258
Strand Reverse strand
Band p13.2
Transcripts
ENST00000353231 ENSP00000266456
ENST00000349926 ENSP00000344723
ENST00000304084 ENSP00000302569
ENST00000298523 ENSP00000298523
ENST00000310002 ENSP00000312089
ENST00000396484 ENSP00000379743
ENST00000465100 ENSP00000436923
ENST00000534609
ENST00000529761 ENSP00000432876
ENST00000533022 ENSP00000431461
ENST00000531192 ENSP00000434392
ENST00000528799
ENST00000525605 ENSP00000434954
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008329 signaling pattern recognition receptor activity
GO:0030246 carbohydrate binding
GO:0042287 MHC protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006910 phagocytosis, recognition
GO:0006954 inflammatory response
GO:0008037 cell recognition
GO:0009756 carbohydrate mediated signaling
GO:0042110 T cell activation
GO:0042832 defense response to protozoan
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079293
View Gene Order
ENSBTAG00000014546
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9BXN2
TrEMBL
UniProt Splice Variant
Entrez Gene 64581
UniGene
RefSeq NM_022570 NM_197947 NM_197948 NM_197949 NM_197950 NM_197954
HUGO HGNC:14558
OMIM 606264
CCDS CCDS41753 CCDS41754 CCDS53744 CCDS8613 CCDS8614 CCDS8617
HPRD 08396
IMGT
EMBL AC024224 AF313468 AF313469 AF400595 AF400596 AF400597 AF400598 AF400599 AF400600 AF400601 AF400602 AJ312372 AJ312373 AK297028 AK298679 AK298724 AK313247 AY009090 AY026769 AY026770 AY026771 AY359002 BC013385 BC071746 BC093829 BC093831 CH471094
GenPept AAG33923 AAH13385 AAH71746 AAH93829 AAH93831 AAK20114 AAK20115 AAK20116 AAK37473 AAK37474 AAL11711 AAL11712 AAL11713 AAL11714 AAL11715 AAL11716 AAL11717 AAL11718 AAQ89361 BAG36058 BAH12480 BAH12845 BAH12855 CAC43846 CAC43847 EAW96144 EAW96145 EAW96146 EAW96150 EAW96154
RNA Seq Atlas 64581

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca