InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sult2b1

Summary

InnateDB Protein

IDBP-184314.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sult2b1

Protein Name

sulfotransferase family, cytosolic, 2B, member 1

Synonyms

AI326997; BB173635; ST2B1; SULT2B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075005

InnateDB Gene

IDBG-184312 (Sult2b1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids such as dehydroepiandrosterone. Isoform 1 is required for production of cholesterol sulfate essential for normal skin development whereas isoform 2 produces pregnenolone sulfate, an essential neurosteroid during development of the central nervous system.

Subcellular Localization

Cytoplasm {ECO:0000250}. Microsome {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in epididymis, intestine and uterus, and low levels in brain and hypothalamus. Isoform 2 is most prominent in the brain and spinal cord, with modest expression in the lung, skin and spleen. Isoform 1 is most prominently expressed in skin and small intestine, with modest expression in muscle and prostate. {ECO:0000269PubMed:12639899, ECO:0000269PubMed:9647753}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004027	alcohol sulfotransferase activity
GO:0005515	protein binding
GO:0008146	sulfotransferase activity
GO:0050294	steroid sulfotransferase activity