Version 5.4
Mus musculus Protein: Tuba8
Summary
InnateDB Protein IDBP-184357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tuba8
Protein Name tubulin, alpha 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000032233
InnateDB Gene IDBG-184355 (Tuba8)
Protein Structure
UniProt Annotation
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Subcellular Localization Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity Expressed at highest levels in the testis, followed by skeletal and heart muscle. Expressed at low levels in the developing brain. {ECO:0000269PubMed:20466094}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006184 GTP catabolic process
GO:0051258 protein polymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:1858225
InterPro IPR000217 Tubulin
IPR002452 Alpha tubulin
IPR002453 Beta tubulin
IPR002967 Delta tubulin
IPR003008 Tubulin/FtsZ, GTPase domain
IPR004057 Epsilon tubulin
IPR008280 Tubulin/FtsZ, C-terminal
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
PFAM PF00091
PF03953
PRINTS PR01161
PR01162
PR01163
PR01224
PR01519
PIRSF
SMART SM00864
SM00865
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJZ2
PhosphoSite PhosphoSite-Q9JJZ2
TrEMBL
UniProt Splice Variant
Entrez Gene 53857
UniGene Mm.32884
RefSeq NP_059075
MGI ID
MGI Symbol Tuba8
OMIM
CCDS CCDS39615
HPRD
IMGT
EMBL AJ245923 AK009439 BC017631 CH466523 GU591980
GenPept AAH17631 ADD82895 BAB26288 CAB88033 EDK99659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca