InnateDB Protein
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IDBP-18436.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLEC7A
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Protein Name
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C-type lectin domain family 7, member A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302569
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InnateDB Gene
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IDBG-18428 (CLEC7A)
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Protein Structure
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Function |
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:11745369, ECO:0000269PubMed:16870151, ECO:0000269PubMed:17230442}; Single- pass type II membrane protein {ECO:0000269PubMed:11745369, ECO:0000269PubMed:16870151, ECO:0000269PubMed:17230442}.Isoform 5: Cytoplasm.Isoform 6: Cytoplasm {ECO:0000305}.Isoform 7: Cytoplasm {ECO:0000305}.
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Disease Associations |
Candidiasis, familial, 4 (CANDF4) [MIM:613108]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269PubMed:19864674}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269PubMed:11470510, ECO:0000269PubMed:11491532, ECO:0000269PubMed:11567029, ECO:0000269PubMed:11745369, ECO:0000269PubMed:12423684}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001304
C-type lectin
IPR002353
Type-2 ice-structuring protein
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
PR00356
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BXN2
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PhosphoSite |
PhosphoSite-Q9BXN2
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TrEMBL |
A0A024RAN9
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UniProt Splice Variant |
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Entrez Gene |
64581
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UniGene |
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RefSeq |
NP_922938
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HUGO |
HGNC:14558
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OMIM |
606264
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CCDS |
CCDS41753
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HPRD |
08396
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IMGT |
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EMBL |
AC024224
AF313468
AF313469
AF400595
AF400596
AF400597
AF400598
AF400599
AF400600
AF400601
AF400602
AJ312372
AJ312373
AK297028
AK298679
AK298724
AK313247
AY009090
AY026769
AY026770
AY026771
AY359002
BC013385
BC071746
BC093829
BC093831
CH471094
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GenPept |
AAG33923
AAH13385
AAH71746
AAH93829
AAH93831
AAK20114
AAK20115
AAK20116
AAK37473
AAK37474
AAL11711
AAL11712
AAL11713
AAL11714
AAL11715
AAL11716
AAL11717
AAL11718
AAQ89361
BAG36058
BAH12480
BAH12845
BAH12855
CAC43846
CAC43847
EAW96144
EAW96145
EAW96146
EAW96150
EAW96152
EAW96154
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