InnateDB Protein
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IDBP-18438.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLEC7A
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Protein Name
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C-type lectin domain family 7, member A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000298523
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InnateDB Gene
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IDBG-18428 (CLEC7A)
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Protein Structure
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Function |
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:11745369, ECO:0000269PubMed:16870151, ECO:0000269PubMed:17230442}; Single- pass type II membrane protein {ECO:0000269PubMed:11745369, ECO:0000269PubMed:16870151, ECO:0000269PubMed:17230442}.Isoform 5: Cytoplasm.Isoform 6: Cytoplasm {ECO:0000305}.Isoform 7: Cytoplasm {ECO:0000305}.
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Disease Associations |
Candidiasis, familial, 4 (CANDF4) [MIM:613108]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269PubMed:19864674}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269PubMed:11470510, ECO:0000269PubMed:11491532, ECO:0000269PubMed:11567029, ECO:0000269PubMed:11745369, ECO:0000269PubMed:12423684}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008646
Herpesvirus UL45-like
IPR016187
C-type lectin fold
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PFAM |
PF05473
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BXN2
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PhosphoSite |
PhosphoSite-Q9BXN2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64581
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UniGene |
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RefSeq |
NP_922940
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HUGO |
HGNC:14558
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OMIM |
606264
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CCDS |
CCDS53744
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HPRD |
08396
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IMGT |
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EMBL |
AC024224
AF313468
AF313469
AF400595
AF400596
AF400597
AF400598
AF400599
AF400600
AF400601
AF400602
AJ312372
AJ312373
AK297028
AK298679
AK298724
AK313247
AY009090
AY026769
AY026770
AY026771
AY359002
BC013385
BC071746
BC093829
BC093831
CH471094
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GenPept |
AAG33923
AAH13385
AAH71746
AAH93829
AAH93831
AAK20114
AAK20115
AAK20116
AAK37473
AAK37474
AAL11711
AAL11712
AAL11713
AAL11714
AAL11715
AAL11716
AAL11717
AAL11718
AAQ89361
BAG36058
BAH12480
BAH12845
BAH12855
CAC43846
CAC43847
EAW96144
EAW96145
EAW96146
EAW96150
EAW96154
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