InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hcn1

Summary

InnateDB Protein

IDBP-184590.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcn1

Protein Name

hyperpolarization-activated, cyclic nucleotide-gated K+ 1

Synonyms

Bcng1; C630013B14Rik; HAC2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006991

InnateDB Gene

IDBG-184588 (Hcn1)

Protein Structure

UniProt Annotation

Function

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269PubMed:11459060, ECO:0000269PubMed:11675786, ECO:0000269PubMed:12034718, ECO:0000269PubMed:22006928, ECO:0000269PubMed:9630217}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11459060, ECO:0000269PubMed:22006928, ECO:0000269PubMed:9630217}; Multi- pass membrane protein {ECO:0000269PubMed:11459060, ECO:0000269PubMed:22006928, ECO:0000269PubMed:9630217}.

Disease Associations

Tissue Specificity

Predominantly expressed in brain. Highly expressed in apical dendrites of pyramidal neurons in the cortex, in the layer corresponding to the stratum lacunosum-moleculare in the hippocampus and in axons of basket cells in the cerebellum. Expressed in a subset of elongated cells in taste buds. {ECO:0000269PubMed:11675786, ECO:0000269PubMed:9405696}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0042802	identical protein binding

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0045176	apical protein localization
GO:0046549	retinal cone cell development
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:1096392

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR005821 Ion transport domain
IPR013621 Ion transport N-terminal
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF00520
PF08412

PRINTS

PR01463

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt