Mus musculus Protein: A2m
Summary
InnateDB Protein IDBP-184736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A2m
Protein Name alpha-2-macroglobulin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000032203
InnateDB Gene IDBG-184734 (A2m)
Protein Structure
UniProt Annotation
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). {ECO:0000250UniProtKB:P01023}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in uterus, mesometrial lympoid aggregate and mammary tissue during pregnancy. Expressed in ovary, testis and kidney. Low level expression in heart. Not expressed in liver. {ECO:0000269PubMed:15355875}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Predicted by orthology
Total 86 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0019899 enzyme binding
GO:0019959 interleukin-8 binding
GO:0019966 interleukin-1 binding
GO:0030414 peptidase inhibitor activity
GO:0043120 tumor necrosis factor binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0007565 female pregnancy
GO:0010951 negative regulation of endopeptidase activity
GO:0048863 stem cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID MGI:2449119
InterPro IPR001599 Alpha-2-macroglobulin
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR007990 Seminal vesicle autoantigen
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
PFAM PF00207
PF01835
PF05326
PF07677
PF07703
PF07678
PF10569
PRINTS
PIRSF PIRSF002572
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6GQT1
PhosphoSite PhosphoSite-Q6GQT1
TrEMBL
UniProt Splice Variant
Entrez Gene 232345
UniGene Mm.30151
RefSeq NP_783327
MGI ID
MGI Symbol A2m
OMIM
CCDS CCDS39617
HPRD
IMGT
EMBL AC153581 AY185125 BC072642
GenPept AAH72642 AAO25741