InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfcp2

Summary

InnateDB Protein

IDBP-184758.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfcp2

Protein Name

transcription factor CP2

Synonyms

CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d; LBP1; LSF; Tcfcp2; UBP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009877

InnateDB Gene

IDBG-184756 (Tfcp2)

Protein Structure

UniProt Annotation

Function

Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:98509

InterPro

IPR007604 CP2 transcription factor
IPR013761 Sterile alpha motif/pointed domain

PFAM

PF04516

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERA0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

21422

UniGene

Mm.219040

RefSeq

NP_258437

MGI ID

MGI Symbol

Tfcp2

OMIM

CCDS

CCDS27840

HPRD

IMGT

EMBL

AK146503 AK147898 AK158682 BC022131 M84809

GenPept

AAF99390 AAH22131 BAE27218 BAE28214 BAE34609