Mus musculus Protein: Ctnnd1
Summary
InnateDB Protein IDBP-184772.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctnnd1
Protein Name catenin (cadherin associated protein), delta 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000065252
InnateDB Gene IDBG-184766 (Ctnnd1)
Protein Structure
UniProt Annotation
Function Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. {ECO:0000250, ECO:0000269PubMed:15138284, ECO:0000269PubMed:15817151, ECO:0000269PubMed:17344476}.
Subcellular Localization Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005488 binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0045296 cadherin binding
Biological Process
GO:0001738 morphogenesis of a polarized epithelium
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0007420 brain development
GO:0007435 salivary gland morphogenesis
GO:0016055 Wnt signaling pathway
GO:0016337 single organismal cell-cell adhesion
GO:0030216 keratinocyte differentiation
GO:0060690 epithelial cell differentiation involved in salivary gland development
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0005923 tight junction
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0030496 midbody
GO:0043197 dendritic spine
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:105100
InterPro IPR000225 Armadillo
IPR016024 Armadillo-type fold
PFAM PF00514
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30999
PhosphoSite PhosphoSite-P30999
TrEMBL
UniProt Splice Variant
Entrez Gene 12388
UniGene Mm.412738
RefSeq NP_001078922
MGI ID
MGI Symbol Ctnnd1
OMIM
CCDS CCDS50622
HPRD
IMGT
EMBL AB093237 AK133193 AK161790 BC043108 BC054544 Z17804
GenPept AAH43108 AAH54544 BAC41421 BAE21551 BAE36576 CAA79078