InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC6A11

Summary

InnateDB Protein

IDBP-18495.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A11

Protein Name

solute carrier family 6 (neurotransmitter transporter, GABA), member 11

Synonyms

GAT-3; GAT3; GAT4;

Species

Homo sapiens

Ensembl Protein

ENSP00000254488

InnateDB Gene

IDBG-18491 (SLC6A11)

Protein Structure

UniProt Annotation

Function

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widespread distribution in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004014	adenosylmethionine decarboxylase activity
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005332	gamma-aminobutyric acid:sodium symporter activity
GO:0042165	neurotransmitter binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007420	brain development
GO:0008295	spermidine biosynthetic process
GO:0015812	gamma-aminobutyric acid transport
GO:0042493	response to drug
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR000175 Sodium:neurotransmitter symporter
IPR002982 Sodium:neurotransmitter symporter, GABA, GAT-3
IPR016067 S-adenosylmethionine decarboxylase, core

PFAM

PF00209

PRINTS

PR00176
PR01197

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48066