InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnb5

Summary

InnateDB Protein

IDBP-184988.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnb5

Protein Name

guanine nucleotide binding protein (G protein), beta 5

Synonyms

flr; Gbeta5; GBS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076155

InnateDB Gene

IDBG-184986 (Gnb5)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Disease Associations

Tissue Specificity

Brain and at much reduced levels in kidney. Isoform 1 is retinal specific. {ECO:0000269PubMed:8910430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0031682	G-protein gamma-subunit binding
GO:0051087	chaperone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:1901386	negative regulation of voltage-gated calcium channel activity

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:101848

InterPro

IPR001632 G-protein, beta subunit
IPR001680 WD40 repeat
IPR011011 Zinc finger, FYVE/PHD-type
IPR016346 Guanine nucleotide-binding protein, beta subunit
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400

PRINTS

PR00319
PR00320

PIRSF

PIRSF002394

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References