Version 5.4
Mus musculus Gene: Gnb5
Summary
InnateDB Gene IDBG-184986.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnb5
Gene Name guanine nucleotide binding protein (G protein), beta 5
Synonyms flr; Gbeta5; GBS
Species Mus musculus
Ensembl Gene ENSMUSG00000032192
Encoded Proteins
IDBP-184988
guanine nucleotide binding protein (G protein), beta 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069966:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:75311395-75344964
Strand Forward strand
Band D
Transcripts
ENSMUST00000076889 ENSMUSP00000076155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0031682 G-protein gamma-subunit binding
GO:0051087 chaperone binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:1901386 negative regulation of voltage-gated calcium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000069966
View Gene Order
ENSBTAG00000003762
Not yet available
Pathways
NETPATH
REACTOME
REACT_231304
Glucagon-type ligand receptors pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_250061
Class B/2 (Secretin family receptors) pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188937
Metabolism pathway
REACT_226335
Aquaporin-mediated transport pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_213947
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_231468
GPCR ligand binding pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_188260
Visual phototransduction pathway
REACT_188266
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_188265
The phototransduction cascade pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
REACT_248547
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_250590
Adrenaline,noradrenaline inhibits insulin secretion pathway
KEGG
mmu04062
Chemokine signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23946
Prostacyclin signalling through prostacyclin receptor pathway
REACT_23876
Platelet homeostasis pathway
REACT_20653
ADP signalling through P2Y purinoceptor 12 pathway
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_20647
Thromboxane signalling through TP receptor pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_19145
G beta:gamma signalling through PLC beta pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_18377
Glucagon-type ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_21254
Presynaptic function of Kainate receptors pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21340
GPCR ligand binding pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_20524
Signal amplification pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04062
Chemokine signaling pathway pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
cone_pathway
Visual signal transduction: Cones
rhodopsin_pathway
Visual signal transduction: Rods
Cross-References
SwissProt P62881
TrEMBL Q3UG14 Q9CU21
UniProt Splice Variant
Entrez Gene 14697
UniGene
RefSeq NM_010313 NM_138719
OMIM
CCDS CCDS40692
HPRD
IMGT
MGI ID MGI:101848
MGI Symbol Gnb5
EMBL AK018747 AK148175 AK149908 AK169323 BC016135 L34290 U69145
GenPept AAA93084 AAC52886 AAH16135 BAB31386 BAE28395 BAE29159 BAE41077
RNA Seq Atlas 14697

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca