InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apaf1

Summary

InnateDB Protein

IDBP-185034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apaf1

Protein Name

apoptotic peptidase activating factor 1

Synonyms

6230400I06Rik; Apaf-1; Apaf1l; fog; mKIAA0413;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020157

InnateDB Gene

IDBG-185032 (Apaf1)

Protein Structure

UniProt Annotation

Function

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in lung and spleen, weakly in brain and kidney and not detectable in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042802	identical protein binding
GO:0043531	ADP binding

Biological Process

GO:0001843	neural tube closure
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952	defense response
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900	forebrain development
GO:0042981	regulation of apoptotic process
GO:0051402	neuron apoptotic process
GO:1902510	regulation of apoptotic DNA fragmentation
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0043293	apoptosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1306796

InterPro

IPR000767 Disease resistance protein
IPR001315 CARD domain
IPR001680 WD40 repeat
IPR002182 NB-ARC
IPR011029 Death-like domain
IPR017251 Apoptotic protease-activating factor 1
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029067 CDC48 domain 2-like

PFAM

PF00619
PF00400
PF00931

PRINTS

PR00364
PR00320

PIRSF

PIRSF037646

SMART

SM00114
SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References