InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apaf1

Summary

InnateDB Gene

IDBG-185032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apaf1

Gene Name

apoptotic peptidase activating factor 1

Synonyms

6230400I06Rik; Apaf-1; Apaf1l; fog; mKIAA0413

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019979

Encoded Proteins

IDBP-185034

apoptotic peptidase activating factor 1

IDBP-540294

apoptotic peptidase activating factor 1

IDBP-540588

apoptotic peptidase activating factor 1

IDBP-535328

apoptotic peptidase activating factor 1

IDBP-539998

apoptotic peptidase activating factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120868:
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:90989311-91082770

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020157	ENSMUSP00000020157
ENSMUST00000159110	ENSMUSP00000125291
ENSMUST00000160725
ENSMUST00000162618	ENSMUSP00000124134
ENSMUST00000159457
ENSMUST00000161095
ENSMUST00000161987	ENSMUSP00000124422
ENSMUST00000160788	ENSMUSP00000124968

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042802	identical protein binding
GO:0043531	ADP binding

Biological Process

GO:0001843	neural tube closure
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952	defense response
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900	forebrain development
GO:0042981	regulation of apoptotic process
GO:0051402	neuron apoptotic process
GO:1902510	regulation of apoptotic DNA fragmentation
GO:2001235	positive regulation of apoptotic signaling pathway