Version 5.4
Mus musculus Protein: Glra2
Summary
InnateDB Protein IDBP-185154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glra2
Protein Name glycine receptor, alpha 2 subunit
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060827
InnateDB Gene IDBG-185152 (Glra2)
Protein Structure
UniProt Annotation
Function The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
GO:0016594 glycine binding
GO:0016934 extracellular-glycine-gated chloride channel activity
GO:0022824 transmitter-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007218 neuropeptide signaling pathway
GO:0007416 synapse assembly
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:95748
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008127 Glycine receptor alpha
IPR008129 Glycine receptor alpha2
PFAM PF02932
PF02931
PRINTS PR00253
PR00252
PR01673
PR01675
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TNC8
PhosphoSite PhosphoSite-Q7TNC8
TrEMBL Q3UTL8
UniProt Splice Variant
Entrez Gene 237213
UniGene Mm.113877
RefSeq NP_906272
MGI ID
MGI Symbol Glra2
OMIM
CCDS CCDS41206
HPRD
IMGT
EMBL AK139335 BC056342 BC068987
GenPept AAH56342 AAH68987 BAE23962

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca