InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnc4

Summary

InnateDB Protein

IDBP-185228.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnc4

Protein Name

potassium voltage gated channel, Shaw-related subfamily, member 4

Synonyms

AI850292; Kcr2-4; KSHIIIC; Kv3.4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009617

InnateDB Gene

IDBG-185226 (Kcnc4)

Protein Structure

UniProt Annotation

Function

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0046928	regulation of neurotransmitter secretion
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0031594	neuromuscular junction
GO:0043679	axon terminus

Protein Structure and Domains

PDB ID

MGI:96670

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003974 Potassium channel, voltage dependent, Kv3
IPR005405 Potassium channel, voltage dependent, Kv3.4
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
IPR021105 Potassium channel, voltage dependent, Kv3, inactivation domain

PFAM

PF02214
PF00520
PF07885
PF11404

PRINTS

PR00169
PR01491
PR01498
PR01583

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt