Version 5.4
Mus musculus Protein: Klrg1
Summary
InnateDB Protein IDBP-185263.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klrg1
Protein Name killer cell lectin-like receptor subfamily G, member 1
Synonyms 2F1-Ag; MAFA; MAFA-L;
Species Mus musculus
Ensembl Protein ENSMUSP00000032207
InnateDB Gene IDBG-185261 (Klrg1)
Protein Structure
UniProt Annotation
Function Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269PubMed:19604491}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269PubMed:19604491}.
Disease Associations
Tissue Specificity Expressed specifically on natural killer (NK) cells and activated CD8 T-cells. Not detected in spleen, thymus, lymph node, testis, brain or kidney. Not detected on mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. {ECO:0000269PubMed:9862378, ECO:0000269PubMed:9862665}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0045087 innate immune response
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1355294
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88713
PhosphoSite PhosphoSite-O88713
TrEMBL
UniProt Splice Variant
Entrez Gene 50928
UniGene Mm.20434
RefSeq NP_058666
MGI ID 3FF9
MGI Symbol Klrg1
OMIM
CCDS CCDS20492
HPRD
IMGT
EMBL AF097357 AF317727 AJ010751 BC101953 BC103546 BC103547 BC103548
GenPept AAD03718 AAI01954 AAI03547 AAI03548 AAI03549 AAK40082 CAA09342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca