InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sparcl1

Summary

InnateDB Protein

IDBP-185290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sparcl1

Protein Name

SPARC-like 1

Synonyms

Ecm2; hevin; mast9; Sc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031249

InnateDB Gene

IDBG-185288 (Sparcl1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Highest expression in brain. Moderate levels in heart, adrenal gland, epididymis and lung. Low levels in kidney, eye, liver, spleen, submandibular gland and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007165

signal transduction

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:108110

InterPro

IPR002048 EF-hand domain
IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR015369 Follistatin/Osteonectin EGF domain
IPR016359 SPARC-like protein 1
IPR019577 SPARC/Testican, calcium-binding domain

PFAM