Version 5.4
Mus musculus Protein: Ube2l6
Summary
InnateDB Protein IDBP-185312.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2l6
Protein Name ubiquitin-conjugating enzyme E2L 6
Synonyms 2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8;
Species Mus musculus
Ensembl Protein ENSMUSP00000099702
InnateDB Gene IDBG-185308 (Ube2l6)
Protein Structure
UniProt Annotation
Function Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0019787 small conjugating protein ligase activity
GO:0042296 ISG15 ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0019941 modification-dependent protein catabolic process
GO:0032020 ISG15-protein conjugation
Cellular Component
Protein Structure and Domains
PDB ID MGI:1914500
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZU9
PhosphoSite PhosphoSite-Q9QZU9
TrEMBL
UniProt Splice Variant
Entrez Gene 56791
UniGene Mm.38261
RefSeq NP_064333
MGI ID
MGI Symbol Ube2l6
OMIM
CCDS CCDS16194
HPRD
IMGT
EMBL AF159230 AK010942 AK013452 AK152010 AK152113 AK168695 AK171629 BC008238 CH466519
GenPept AAD55978 AAH08238 BAB27282 BAB28861 BAE30873 BAE30957 BAE40539 BAE42574 EDL27303

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca