InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ube2l6

Summary

InnateDB Gene

IDBG-185308.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2l6

Gene Name

ubiquitin-conjugating enzyme E2L 6

Synonyms

2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027078

Encoded Proteins

IDBP-185312

ubiquitin-conjugating enzyme E2L 6

IDBP-536812

ubiquitin-conjugating enzyme E2L 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156587:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:84798828-84810335

Strand

Forward strand

Band

Transcripts

ENSMUST00000102642	ENSMUSP00000099702
ENSMUST00000150325	ENSMUSP00000119507
ENSMUST00000154709
ENSMUST00000159150

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0019787	small conjugating protein ligase activity
GO:0042296	ISG15 ligase activity