InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smtnl1

Summary

InnateDB Protein

IDBP-185352.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smtnl1

Protein Name

smoothelin-like 1

Synonyms

1110030K22Rik; CHASM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028471

InnateDB Gene

IDBG-185350 (Smtnl1)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity. {ECO:0000269PubMed:18310078, ECO:0000269PubMed:20634291}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Nucleus. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in skeletal muscles (at protein level). Within striated muscles, significantly more expressed in soleus muscle compared with plantaris muscle or white vastus (at protein level). 30-40% lower expression in females than in males (at protein level). Expressed in type 2a fibers, but not detected in fast twitch type 2b muscle white vastus nor in oxidative type I/b heart muscle (at protein level). Expressed within myometrial cells of the uterus, as well as in the endometrial layer. In the aorta, confined to smooth muscle cells. Not detected in endothelial cells. {ECO:0000269PubMed:18310078, ECO:0000269PubMed:20634291}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008157	protein phosphatase 1 binding
GO:0017020	myosin phosphatase regulator activity

Biological Process

GO:0014823	response to activity
GO:0018105	peptidyl-serine phosphorylation
GO:0042493	response to drug
GO:0043086	negative regulation of catalytic activity
GO:0045907	positive regulation of vasoconstriction
GO:0045908	negative regulation of vasodilation
GO:0048644	muscle organ morphogenesis
GO:0050790	regulation of catalytic activity