Version 5.4
Mus musculus Gene: Smtnl1
Summary
InnateDB Gene IDBG-185350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smtnl1
Gene Name smoothelin-like 1
Synonyms 1110030K22Rik; CHASM
Species Mus musculus
Ensembl Gene ENSMUSG00000027077
Encoded Proteins
IDBP-185352
smoothelin-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000214872:
SMTNL1, which is a member of the smoothelin (SMTN; MIM 602127) family, regulates contraction and relaxation of skeletal and smooth muscle fibers and mediates vascular adaptation to exercise (Wooldridge et al., 2008 [PubMed 18310078]).[supplied by OMIM, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:84811176-84822652
Strand Reverse strand
Band D
Transcripts
ENSMUST00000028471 ENSMUSP00000028471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008157 protein phosphatase 1 binding
GO:0017020 myosin phosphatase regulator activity
Biological Process
GO:0014823 response to activity
GO:0018105 peptidyl-serine phosphorylation
GO:0042493 response to drug
GO:0043086 negative regulation of catalytic activity
GO:0045907 positive regulation of vasoconstriction
GO:0045908 negative regulation of vasodilation
GO:0048644 muscle organ morphogenesis
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031430 M band
GO:0031674 I band
GO:0043292 contractile fiber
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000214872
View Gene Order
ENSBTAG00000027524
Not yet available
Cross-References
SwissProt Q99LM3
TrEMBL
UniProt Splice Variant
Entrez Gene 68678
UniGene Mm.33452
RefSeq NM_024230 XM_006500109
OMIM
CCDS CCDS16195
HPRD
IMGT
MGI ID MGI:1915928
MGI Symbol Smtnl1
EMBL AL928914 BC002317
GenPept AAH02317 CAM23315
RNA Seq Atlas 68678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca