InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Egfl6

Summary

InnateDB Protein

IDBP-185397.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Egfl6

Protein Name

EGF-like-domain, multiple 6

Synonyms

Maeg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000412

InnateDB Gene

IDBG-185395 (Egfl6)

Protein Structure

UniProt Annotation

Function

May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. {ECO:0000269PubMed:15572035, ECO:0000269PubMed:18757743}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269PubMed:18757743}.

Disease Associations

Tissue Specificity

Expressed at basement membrane of pelage follicles (at protein level). {ECO:0000269PubMed:15572035}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007275	multicellular organismal development
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005604	basement membrane
GO:0016020	membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1858599

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000998 MAM domain
IPR001881 EGF-like calcium-binding domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00629
PF07645

PRINTS

PR00020

PIRSF

SMART

SM00181
SM00137
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt