Version 5.4
Homo sapiens Protein: LNX1
Summary
InnateDB Protein IDBP-18548.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LNX1
Protein Name ligand of numb-protein X 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302879
InnateDB Gene IDBG-18546 (LNX1)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity). {ECO:0000250}.Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in heart, placenta, kidney, pancreas and brain. {ECO:0000269PubMed:11521506}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 173 [view]
Protein-Protein 173 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TBB1
PhosphoSite PhosphoSite-Q8TBB1
TrEMBL
UniProt Splice Variant
Entrez Gene 84708
UniGene Hs.629493
RefSeq NP_116011
HUGO HGNC:6657
OMIM 609732
CCDS CCDS3492
HPRD 17287
IMGT
EMBL AC058822 AC095040 AF237782 AK056823 AY358326 BC022983 BC034737
GenPept AAH22983 AAH34737 AAK15039 AAQ88692 AAY41000 BAB71291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca