InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf11a

Summary

InnateDB Protein

IDBP-185531.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf11a

Protein Name

tumor necrosis factor receptor superfamily, member 11a

Synonyms

Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027559

InnateDB Gene

IDBG-185529 (Tnfrsf11a)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269PubMed:20483727, ECO:0000269PubMed:9878548}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0019955	cytokine binding
GO:0046872	metal ion binding

Biological Process

GO:0001503	ossification
GO:0002250	adaptive immune response
GO:0007275	multicellular organismal development
GO:0009314	response to radiation
GO:0030316	osteoclast differentiation
GO:0032496	response to lipopolysaccharide
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034097	response to cytokine
GO:0034612	response to tumor necrosis factor
GO:0043507	positive regulation of JUN kinase activity
GO:0048535	lymph node development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060086	circadian temperature homeostasis
GO:0060749	mammary gland alveolus development
GO:0070555	response to interleukin-1
GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847	TNFSF11-mediated signaling pathway
GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling