InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnfrsf11a

Summary

InnateDB Gene

IDBG-185529.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf11a

Gene Name

tumor necrosis factor receptor superfamily, member 11a

Synonyms

Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026321

Encoded Proteins

IDBP-185531

tumor necrosis factor receptor superfamily, member 11a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141655:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:105780718-105847981

Strand

Forward strand

Band

E2.1

Transcripts

ENSMUST00000027559	ENSMUSP00000027559
ENSMUST00000187812
ENSMUST00000187658

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0019955	cytokine binding
GO:0046872	metal ion binding

Biological Process

GO:0001503	ossification
GO:0002250	adaptive immune response
GO:0007275	multicellular organismal development
GO:0009314	response to radiation
GO:0030316	osteoclast differentiation
GO:0032496	response to lipopolysaccharide
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034097	response to cytokine
GO:0034612	response to tumor necrosis factor
GO:0043507	positive regulation of JUN kinase activity
GO:0048535	lymph node development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060086	circadian temperature homeostasis
GO:0060749	mammary gland alveolus development
GO:0070555	response to interleukin-1
GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847	TNFSF11-mediated signaling pathway
GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling

Cellular Component

GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000141655

View Gene Order

ENSBTAG00000007569

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04380

Osteoclast differentiation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

NetPath_21

RANKL pathway

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_009399 XM_006529381

OMIM

CCDS

CCDS15207

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas