InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Csf1

Summary

InnateDB Protein

IDBP-185537.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Csf1

Protein Name

colony stimulating factor 1 (macrophage)

Synonyms

C87615; Csfm; MCSF; op;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014743

InnateDB Gene

IDBG-185535 (Csf1)

Protein Structure

UniProt Annotation

Function

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Processed macrophage colony-stimulating factor 1: Secreted, extracellular space {ECO:0000250}.

Disease Associations

Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling. {ECO:0000269PubMed:2188141}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	6 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005157	macrophage colony-stimulating factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001503	ossification
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002158	osteoclast proliferation
GO:0003006	developmental process involved in reproduction
GO:0006954	inflammatory response
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0030225	macrophage differentiation
GO:0030278	regulation of ossification
GO:0030316	osteoclast differentiation
GO:0030335	positive regulation of cell migration
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0040018	positive regulation of multicellular organism growth
GO:0042476	odontogenesis
GO:0042488	positive regulation of odontogenesis of dentin-containing tooth
GO:0045087	innate immune response
GO:0045651	positive regulation of macrophage differentiation
GO:0045657	positive regulation of monocyte differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048873	homeostasis of number of cells within a tissue
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060611	mammary gland fat development
GO:0060763	mammary duct terminal end bud growth

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome