Version 5.4
Mus musculus Gene: Csf1
Summary
InnateDB Gene IDBG-185535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Csf1
Gene Name colony stimulating factor 1 (macrophage)
Synonyms C87615; Csfm; MCSF; op
Species Mus musculus
Ensembl Gene ENSMUSG00000014599
Encoded Proteins
IDBP-185537
colony stimulating factor 1 (macrophage)
IDBP-400596
colony stimulating factor 1 (macrophage)
IDBP-400594
colony stimulating factor 1 (macrophage)
IDBP-400595
colony stimulating factor 1 (macrophage)
IDBP-541359
colony stimulating factor 1 (macrophage)
IDBP-541351
colony stimulating factor 1 (macrophage)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184371:
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:107741048-107760469
Strand Reverse strand
Band F2.3
Transcripts
ENSMUST00000014743 ENSMUSP00000014743
ENSMUST00000118593 ENSMUSP00000113136
ENSMUST00000120243 ENSMUSP00000113617
ENSMUST00000120654 ENSMUSP00000112832
ENSMUST00000155557
ENSMUST00000156820 ENSMUSP00000119553
ENSMUST00000153114 ENSMUSP00000115480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 6 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005157 macrophage colony-stimulating factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001503 ossification
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002158 osteoclast proliferation
GO:0003006 developmental process involved in reproduction
GO:0006954 inflammatory response
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0030225 macrophage differentiation
GO:0030278 regulation of ossification
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0040018 positive regulation of multicellular organism growth
GO:0042476 odontogenesis
GO:0042488 positive regulation of odontogenesis of dentin-containing tooth
GO:0045087 innate immune response
GO:0045651 positive regulation of macrophage differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048873 homeostasis of number of cells within a tissue
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060611 mammary gland fat development
GO:0060763 mammary duct terminal end bud growth
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000184371
View Gene Order
ENSBTAG00000000283
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
ptp1bpathway
Signaling events mediated by PTP1B
tcptp_pathway
Signaling events mediated by TCPTP
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.481972 Mm.795
RefSeq NM_001113529 NM_001113530 NM_007778
OMIM
CCDS CCDS17740 CCDS51044
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca