InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aicda

Summary

InnateDB Protein

IDBP-185565.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aicda

Protein Name

activation-induced cytidine deaminase

Synonyms

Aid; Arp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040524

InnateDB Gene

IDBG-185563 (Aicda)

Protein Structure

UniProt Annotation

Function

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269PubMed:12692563}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	31 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Biological Process

GO:0006397	mRNA processing
GO:0009972	cytidine deamination
GO:0016445	somatic diversification of immunoglobulins
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0045190	isotype switching
GO:0071222	cellular response to lipopolysaccharide
GO:0080111	DNA demethylation
GO:0090310	negative regulation of methylation-dependent chromatin silencing