InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aicda

Summary

InnateDB Gene

IDBG-185563.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aicda

Gene Name

activation-induced cytidine deaminase

Synonyms

Aid; Arp2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040627

Encoded Proteins

IDBP-185565

activation-induced cytidine deaminase

IDBP-540349

activation-induced cytidine deaminase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24244169

[Homo sapiens] Kaposi's sarcoma-associated herpesvirus (KSHV) infection results in upregulation of AICDA in primary human tonsillar B cells. Two KSHV miRNAs, K12-11 and K12-5 interact with the 3�?�UTR of AICDA to translationally repress its expression.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111732:
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:122553801-122564180

Strand

Forward strand

Band

Transcripts

ENSMUST00000043301	ENSMUSP00000040524
ENSMUST00000160685	ENSMUSP00000125093

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	31 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Biological Process

GO:0006397	mRNA processing
GO:0009972	cytidine deamination
GO:0016445	somatic diversification of immunoglobulins
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0045190	isotype switching
GO:0071222	cellular response to lipopolysaccharide
GO:0080111	DNA demethylation
GO:0090310	negative regulation of methylation-dependent chromatin silencing

Cellular Component

GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111732

View Gene Order

ENSBTAG00000018849

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05340

Primary immunodeficiency pathway

mmu04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05340

Primary immunodeficiency pathway

hsa04672

Intestinal immune network for IgA production pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

il4_2pathway

IL4-mediated signaling events

Cross-References

SwissProt

TrEMBL

E0CXQ9

UniProt Splice Variant

Entrez Gene

11628

UniGene

Mm.391503

RefSeq

NM_009645

OMIM

CCDS

CCDS20497

HPRD

IMGT

MGI ID

MGI:1342279

MGI Symbol

Aicda

EMBL

AC155946

GenPept

RNA Seq Atlas

11628