Version 5.4
Mus musculus Protein: Vegfa
Summary
InnateDB Protein IDBP-185851.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vegfa
Protein Name vascular endothelial growth factor A
Synonyms Vegf; Vpf;
Species Mus musculus
Ensembl Protein ENSMUSP00000024747
InnateDB Gene IDBG-185847 (Vegfa)
Protein Structure
UniProt Annotation
Function Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). {ECO:0000250}.
Subcellular Localization Isoform VEGF-1: Secreted.Isoform VEGF-2: Secreted.Isoform VEGF-3: Cell membrane; Peripheral membrane protein. Note=Remains cell-surface associated unless released by heparin.
Disease Associations
Tissue Specificity In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression of VEGF continues in kidney glomeruli and choroid plexus in adults.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 6 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0046982 protein heterodimerization activity
GO:0048018 receptor agonist activity
GO:0050840 extracellular matrix binding
Biological Process
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001568 blood vessel development
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002092 positive regulation of receptor internalization
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003169 coronary vein morphogenesis
GO:0007498 mesoderm development
GO:0007595 lactation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0010595 positive regulation of endothelial cell migration
GO:0016477 cell migration
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030855 epithelial cell differentiation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077 post-embryonic camera-type eye development
GO:0031334 positive regulation of protein complex assembly
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035148 tube formation
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036303 lymph vessel morphogenesis
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0040007 growth
GO:0042462 eye photoreceptor cell development
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0043129 surfactant homeostasis
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048469 cell maturation
GO:0048514 blood vessel morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048666 neuron development
GO:0048739 cardiac muscle fiber development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051781 positive regulation of cell division
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060319 primitive erythrocyte differentiation
GO:0060426 lung vasculature development
GO:0060749 mammary gland alveolus development
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060982 coronary artery morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:0071679 commissural neuron axon guidance
GO:0090037 positive regulation of protein kinase C signaling
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1901492 positive regulation of lymphangiogenesis
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902533 positive regulation of intracellular signal transduction
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID MGI:103178
InterPro IPR000072 PDGF/VEGF domain
IPR029034 Cystine-knot cytokine
PFAM PF00341
PRINTS
PIRSF
SMART SM00141
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q00731
PhosphoSite PhosphoSite-
TrEMBL Q5UD54
UniProt Splice Variant
Entrez Gene 22339
UniGene Mm.473100
RefSeq NP_001273987
MGI ID
MGI Symbol Vegfa
OMIM
CCDS CCDS70817
HPRD
IMGT
EMBL AC127690 AY263146 AY707864 AY750956 AY750957 AY756068 BC061468 EF028705 M95200 S37052 S38083 S38100 U41383 U50279
GenPept AAA40547 AAB22252 AAB22253 AAB22254 AAC05442 AAH61468 AAP86647 AAU11325 AAU95484 AAU95485 AAV32504 ABK27265

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca